Albert von Szent-Györgyi was born in Budapest
on September 16, 1893, Biography полностью - акустический подиум Albert Szent-Györgyi деревянный the son of Nicolaus von Szent-Györgyi, a great landed
proprietor and Josefine, whose father, Joseph Lenhossék, and brother
Michael were both Professors of Anatomy in the University of Budapest. He matriculated
in 1911 and entered his uncle's laboratory where he studied until the outbreak
of World War I when he was mobilized. He served on the Italian and Russian fronts,
gaining the Silver Medal for Valour, and he was discharged in 1917 after being
wounded in action. He completed his studies in Budapest and then worked successively
with the pharmacologist, G. Mansfeld at Pozsony, with Armin von Tschermak at
Prague, where he studied electrophysiology, and with L. Michaelis in Berlin,
before he went to Hamburg for a two-year course in physical chemistry at the
Institute for Tropical Hygiene.
In 1920 he became an assistant at the University Institute of Pharmocology in
Leiden and from 1922 to 1926 he worked with H. J. Hamburger at the Physiology
Institute, Groningen, The Netherlands. In 1927 he went to Cambridge as a Rockefeller
Fellow, working under F. G. Hopkins, and spent one year at the Mayo Foundation,
Rochester, Minnesota, before returning to Cambridge. In 1930 he obtained the
Chair of Medical Chemistry at the University of Szeged and in 1935 he also took
the Chair in Organic Chemistry. At the end of World War II, he took the Chair
of Medical Chemistry at Budapest and in 1947 he left Hungary to settle in the
United States where he is Director of Research, Institute of Muscle Research,
Woods Hole, Massachusetts.
Szent-Györgyi's early researches at Groningen concerned the chemistry of
cell respiration. He described the interdependence of oxygen and hydrogen activation
and made his first observations on co-dehydrases and the polyphenol oxidase
systems of plants. He also demonstrated the existence of a reducing substance
in plant and animal tissues. At Cambridge and during his early spell in the
United States, he isolated from adrenals this reducing substance, which is now
known as ascorbic acid. Returning to Cambridge in 1929, he later described the
pharmacological activity of the nucleotides with Drury.
On his return to Hungary, he noted the anti-scorbutic activity of ascorbic acid
and discovered that paprika (capsicum annuum) was a rich source of vitamin
C. His persistent studies of biological oxidation led to the recognition of
the catalytic function of the C4-dicarboxylic acids, the discovery
of «cytoflav» (flavin) and a recognition of the biological activity
and probable vitamin nature of flavanone (vitamin P).
In 1938 he commenced work on muscle research and quickly discovered the proteins
actin and myosin and their complex. This led to a reproduction of the fundamental
reaction of muscle contraction which formed the foundation of muscle research
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use of rabbit psoas muscle as an experimental material, published theories on
the problems of energetics and investigated the regulation of growth and cell
membrane potential, and the hormonal function of the thymus gland.
Szent-Györgyi, a member of many scientifc societies, is a Past President
of the Academy of Sciences, Budapest, and a Vice-President of the National Academy,
Budapest. He was Visiting Professor, Harvard University in 1936 and Franchi
Professor, University of Liège, 1938. He received the Cameron Prize (Edinburgh)
in 1946 and the Lasker Award in 1954. His many publications include Oxidation,
Fermentation, Vitamins, Health and Disease (1939); Muscular Contraction
(1947); The Nature of Life (1947); Contraction in Body and Heart Muscle
(1953); and Bioenergetics (1957).
Szent-Györgyi married Cornelia Demény, daughter of the Hungarian
Postmaster-General, in 1917. During the 1930's he was actively anti-Nazi and
during World War II he became a Swedish citizen - he was given extensive help
by the Swedish Embassy in Budapest. In 1941, he married Màrta Borbiro,
a co-worker at Woods Hole: they have one daughter.
He is interested in sport of all kinds, his favourites being sailing and alpinism.This
autobiography/biography was written at the time of the award and later published
in the book series Les Prix Nobel/Nobel Lectures. The information
is sometimes updated with an addendum submitted by the Laureate. To cite this
document, always state the source as shown above.