Christiaan Eijkman was born on August 11, 1858, at
Nijkerk in Gelderland (The Netherlands), the seventh child of Christiaan Eijkman,
the headmaster of a local school, and Johanna Alida Pool.
A year later, in 1859, the Eijkman family moved to Zaandam, where his father
was appointed head of a newly founded school for advanced elementary education.
It was here that Christiaan and his brothers received their early education.
In 1875, after taking his preliminary examinations, Eijkman became a student
at the Military Medical School of the University of Amsterdam, where he was
trained as a medical officer for the Netherlands Indies Army, passing through
all his examinations with honours.
From 1879 to 1881, he was an assistant of T. Place, Professor of Physiology,
during which time he wrote his thesis On Polarization of the Nerves,
which gained him his doctor's degree, with honours, on July 13, 1883. That same
year he left Holland for the Indies, where he was made medical officer of health
first in Semarang later at Tjilatjap, a small village on the south coast of
Java, and at Padang Sidempoean in W. Sumatra. It was at Tjilatjap that he caught
malaria which later so impaired his health that he, in 1885, had to return to
Europe on sick-leave.
For Eijkman this was to prove a lucky event, as it enabled him to work in E.
Forster's laboratory in Amsterdam, and also in Robert Koch's bacteriological
laboratory in Berlin; here he came into contact with A. C. Pekelharing and C.
Winkler, who were visiting the German capital before their departure to the
Indies. In this way medical officer Christiaan Eijkman was seconded as assistant
to the Pekelharing-Winkler mission, together with his colleague M. B. Romeny.
This mission had been sent out by the Dutch Government to conduct investigations
into beriberi, a disease which at that time was causing havoc in that region.
In 1887, Pekelharing and Winkler were recalled, but before their departure Pekelharing
proposed to the Governor General that the laboratory which had been temporarily
set up for the Commission in the Military Hospital in Batavia should be made
permanent. This proposal was readily accepted, and Christiaan Eijkman was appointed
its first Director, at the same time being made Director of the "Dokter Djawa
School" (Javanese Medical School). Thus ended Eijkman's short military career
- now he was able to devote himself entirely to science.
Eijkman was Director of the "Geneeskundig Laboratorium" (Medical Laboratory)
from January 15, 1888 to March 4, 1896, and during that time he made a number
of his most important researches. These dealt first of all with the physiology
of people living in tropical regions. He was able to demonstrate that a number
of theories had no factual basis. Firstly he proved that in the blood of Europeans
living in the tropics the number of red corpuscles, the specific gravity, the
serum, and the water content, undergo no change, at least when the blood is
not affected by disease which will ultimately lead to anaemia. Comparing the
metabolism of the European with that of the native, he found that in the tropics
as well in the temperate zone, this is entirely governed by the work carried
out. Neither could he find any disparity in respiratory metabolism, perspiration,
and temperature regulation. Thus Eijkman put an end to a number of speculations
on the acclimatization of Europeans in the tropics which had hitherto necessitated
the taking of various precautions.
But Eijkman's greatest work was in an entirely different field. He discovered,
after the departure of Pekelharing and Winkler, that the real cause of beriberi
was the deficiency of some vital substance in the staple food of the natives,
which is located in the so-called "silver skin" (pericarpium) of the rice. This
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him the Nobel Prize in Physiology or Medicine for 1929. This late recognition
of his outstanding merits has ended all criticism of his work. In addition to
his work on beriberi, he occupied himself with other problems such as arach
fermentation, and indeed still had time to write two textbooks for his students
at the Java Medical School, one on physiology and the other on organic chemistry.
In 1898 he became successor to G. Van Overbeek de Meyer, as Professor in Hygiene
and Forensic Medicine at Utrecht. His inaugural speech was entitled Over
Gezondheid en Ziekten in Tropische Gewesten (On health and diseases in tropical
regions). At Utrecht, Eijkman turned to the study of bacteriology, and carried
out his well-known fermentation test, by means of which it can be readily established
if water has been polluted by human and animal defaecation containing coli bacilli.
Another research was into the rate of mortality of bacteria as a result of various
external factors, whereby he was able to show that this process could not be
represented by a logarithmic curve. This was followed by his investigation of
the phenomenon that the rate of growth of bacteria on solid substratum often
decreases, finally coming to a halt. Beyerinck's auxanographic method was applied
on several occasions by Eijkman, as for example during the secretion of enzymes
which break down casein or bring about haemolysis, whereby he could demonstrate
the hydrolysis of fats under the influence of lipases.
As a lecturer he was known for his clarity of speech and demonstration, his
great practical knowledge standing him in good stead. He had a preeminently
critical mind and he continuously warned his students against the acceptance
of dogmas. But Eijkman did not confine himself to the University he also engaged
himself in problems of water supply, housing, school hygiene, physical education;
as a member of the Gezondheidsraad (Health Council) and the Gezondheidscommissie
(Health Commission) he participated in the struggle against alcoholism and tuberculosis.
He was the founder of the Vereeniging tot Bestrijding van de Tuberculose (Society
for the struggle against tuberculosis ).
His unassuming personality has contributed to the fact that his great merits
were at first not really appreciated in his own country; but anyone who had
the privilege of coming into close contact with him, quickly perceived his keen
intellect and extensive knowledge.
In 1907, Eijkman was appointed Member of the Royal Academy of Sciences (The
Netherlands), after having been Correspondent since 1895. The Dutch Government
conferred upon him several orders of knighthood, whereas on the occasion of
the 25th anniversary of his professorship a fund has been established to enable
the awarding of the Eijiman Medal. But the crown of all his work was the award
of the Nobel Prize in 1929.
Eijkman was holder of the John Scott Medal, Philadelphia, and Foreign Associate
of the National Academy of Sciences in Washington. He was also Honorary Fellow
of the Royal Sanitary Institute in London.
In 1883, before his departure to the Indies, Eijkman married Aaltje Wigeri van
Edema, who died in 1886. In Batavia, Professor Eijkman married Bertha Julie
Louise van der Kemp in 1888; a son, Pieter Hendrik, who became a physician,
was born in 1890.
He died in Utrecht, on November 5, 1930, after a protracted illness.
This autobiography/biography was written at the time of the award and later published in the book series Les Prix Nobel/Nobel Lectures. The information is sometimes updated with an addendum submitted by the Laureate. To cite this document, always state the source as shown above.