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| May | June | July | August | September | October |
| TSN (0-0) | CBC (0-0) | RSN |
(0-0) |
March (0-0) |
RONT (0-0) |
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| Day | Opp | Time | H\A | TV | Score | W\L | Record | WP (Record) | LP (Record) | Save | Day | ||
| 31 | Mon | NYY | 1:05 pm | A | RSN | PPD.,Rain | 31 | Mon | |||||
| TSN (0-3) | CBC (0-0) | RSN |
(9-12) |
April (11-17) |
RONT (2-2) |
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| 0 | 0 | ||||||||||||
| Day | Opp | Time | H\A | TV | Score | W\L | Record | WP (Record) | LP (Record) | Save | Day | ||
| 1 | Tues | NYY | 7:05 pm | A | TSN | 2-3 | L | (0-1) | Wang (1-0) | Halladay (0-1) | Rivera (1) | 1 | Tues |
| 2 | Wed | NYY | 7:05 pm | A | RSN | 5-2 | W | (1-1) | Burnett (1-0) | Mussina (0-1) | Accardo (1) | 2 | Wed |
| 3 | Thurs | NYY | 7:05 pm | A | TSN | 2-3 | L | (1-2) | Chamberlain (1-0) | Wolfe (0-1) | Rivera (2) | 3 | Thurs |
| 4 | Fri | BOS | 7:15 pm | H | RSN | 6-3 | W | (2-2) | Marcum (1-0) | Aardsma (0-1) | Accardo (2) | 4 | Fri |
| 5 | Sat | BOS | 1:07 pm | H | RSN | 10-2 | W | (3-2) | Litsch (1-0) | Buchholz (0-1) | 5 | Sat | |
| 6 | Sun | BOS | 1:07 pm | H | RSN | 7-4 | W | (4-2) | Halladay (1-1) | Beckett (0-1) | Accardo (3) | 6 | Sun |
| 7 | Mon | 7 | Mon | ||||||||||
| 8 | Tues | OAK | 7:07 pm | H | TSN | 8-9 | L | (4-3) | Embree (1-1) | Accardo (0-1) | Street (1) | 8 | Tues |
| 9 | Wed | OAK | 7:07 pm | H | RSN | 3-6 | L | (4-4) | Hernandez (1-0) | Accardo (0-2) | Street (2) | 9 | Wed |
| 10 | Thur | OAK | 7:07 pm | H | RSN | 2-3 (12) | L | (4-5) | Devine (1-0) | League (0-1) | Foulke (1) | 10 | Thur |
| 11 | Fri | TEX | 8:05 pm | A | 8-5 | W | (5-5) | Litsch (2-0) | Padilla (1-1) | Downs (1) | 11 | Fri | |
| 12 | Sat | TEX | 8:05 pm | A | 4-1 | W | (6-5) | Halladay (2-1) | Mendoza (1-0) | 12 | Sat | ||
| 13 | Sun | TEX | 3:05 pm | A | RSN | 5-4 | W | (7-5) | Carlson (1-0) | Nippert (0-1) | Ryan (1) | 13 | Sun |
| 14 | Mon | BALT | 7:05 pm | A | 3-4 | L | (7-6) | Abers (2-0) | Mc Gowan (0-1) | Sherrill (6) | 14 | Mon | |
| 15 | Tues | BALT | 7:05 pm | A | RSN | 11-3 | W | (8-6) | Marcum (2-0) | Trachsel (1-2) | 15 | Tues | |
| 16 | Wed | TEX | 7:07 pm | H | RSN | 5-7 (14) | L | (8-7) | Nippert (1-1) | Burnett (1-1) | Wilson (4) | 16 | Wed |
| 17 | Thurs | TEX | 7:07 pm | H | RSN | 1-4 | L | (8-8) | Padilla (2-1) | Halladay (2-2) | Wilson (5) | 17 | Thurs |
| 18 | Fri | DET | 7:07 pm | H | RSN | 4-8 | L | (8-9) | Rogers (1-3) | Accardo (0-3) | 18 | Fri | |
| 19 | Sat | DET | 1:07 pm | H | RSN | 3-2 | W | (9-9) | Mc Gowan (1-1) | Bonderman (1-2) | Ryan (2) | 19 | Sat |
| 20 | Sun | DET | 1:07 pm | H | RSN | 5-3 | W | (10-9) | Burnett (2-1) | Robertson (0-2) | Accardo (4) | 20 | Sun |
| 21 | Mon | DET | 12:37 pm | H | 1-5 | L | (10-10) | Galarrago (2-0) | Marcum (2-1) | 21 | Mon | ||
| 22 | Tues | TB | 7:10 pm | A | RSN | 4-6 | L | (10-11) | Shields (2-1) | Litsch (2-1) | Percival (2) | 22 | Tues |
| 23 | Wed | TB | 7:10 pm | A | RSN | 3-5 | L | (10-12) | Hammel (2-1) | Halladay (2-3) | Percival (3) | 23 | Wed |
| 24 | Thurs | TB | 7:10 pm | A | RSN | 3-5 | L | (10-13) | Sonnastine (3-1) | Mc Gowan (1-2) | Percival (4) | 24 | Thurs |
| 25 | Fri | KC | 8:10 pm | A | RSN | 4-8 | L | (10-14) | Nunez (2-0) | Burnett (2-2) | 25 | Fri | |
| 26 | Sat | KC | 7:10 pm | A | RSN | 1-2 | L | (10-15) | Hochevar (1-1) | Marcum (2-2) | Soria (6) | 26 | Sat |
| 27 | Sun | KC | 2:10 pm | A | RSN | 5-2 | W | (11-15) | Litsch (3-1) | Menche (1-4) | Carlson (1) | 27 | Sun |
| 28 | Mon | 28 | Mon | ||||||||||
| 29 | Tues | BOS | 7:05 pm | A | RSN | 0-1 | L | (11-16) | Paplebon (1-0) | Halladay (2-4) | 29 | Tues | |
| 30 | Wed | BOS | 7:05 pm | A | RSN | 1-2 | L | (11-17) | Paplebon (2-0) | Downs (0-1) | 30 | Wed | |
| TSN (0-0) | CBC (0-0) | RSN |
(7-5) |
May (7-5) | RONT (0-0) | ||||||||
| 0 | 0 | 9 | |||||||||||
| Day | Opp | Time | H\A | TV | Score | W\L | Record | WP (Record) | LP (Record) | Save | Day | ||
| 1 | Thurs | BOS | 7:05 pm | A | RSN | 3-0 | W | (12-17) | Burnett (3-2) | Wakefield (2-1) | Ryan (3) | 1 | Tue |
| 2 | Fri | CWS | 7:07 pm | H | RSN | 2-0 | W | (13-17) | Marcum (3-2) | Buehrle (1-3) | Downs (2) | 2 | Wed |
| 3 | Sat | CWS | 1:07 pm | H | RSN | 5-2 | W | (14-17) | Litsch (4-1) | Danks (2-3) | Ryan (4) | 3 | Thurs |
| 4 | Sun | CWS | 1:07 pm | H | RSN | 4-3 | W | (15-17) | Halladay (3-4) | Contreras (2-3) | Downs (3) | 4 | Fri |
| 5 | Mon | CWS | 7:07 pm | H | RSN | 1-0 | W | (16-17) | Mc Gowan (2-2) | Vazquez (3-3) | Ryan (5) | 5 | Sat |
| 6 | Tues | TB | 7:07 pm | H | RSN | 4-5 | L | (16-18) | Sonnanstine (5-1) | Burnett (3-3) | Percival (7) | 6 | Sun |
| 7 | Wed | TB | 7:07 pm | H | RSN | 6-2 | W | (17-18) | Marcum (4-2) | Garaza (1-1) | 7 | Mon | |
| 8 | Thur | TB | 7:07 pm | H | RSN | 3-8 (13) | L | (17-19) | Howell (1-0) | Camp (0-1) | 8 | Tues | |
| 9 | Fri | CLEV | 7:05 pm | A | RSN | 1-6 | L | (17-20) | Sabathia (2-5) | Halladay (3-5) | 9 | Wed | |
| 10 | Sat | CLEV | 7:05 pm | A | RSN | 0-12 | L | (17-21) | Laffey (1-2) | Mc Gowan (2-3) | 10 | Thurs | |
| 11 | Sun | CLEV | 1:05 pm | A | RSN | PPD.,RAIN | Rescheduled to May 12 | 11 | Fri | ||||
| 12 | Mon | CLEV | 4:05 pm (1) | A | RSN | 0-3 | L | (17-22) | Carmona (4-1) | Burnett (3-4) | 12 | Sat | |
| 12 | Mon | CLEV | TBA (2) | A | RSN | 3-0 (10) | W | (18-22) | Ryan (1-0) | Betancourt (1-2) | Downs (4) | 12 | Sat |
| 13 | Tues | MINN | 8:10 pm | A | RSN | 13 | Sun | ||||||
| 14 | Wed | MINN | 8:10 pm | A | RSN | 14 | Mon | ||||||
| 15 | Thurs | MINN | 1:10 pm | A | 15 | Tues | |||||||
| 16 | Fri | PHIL | 7:05 pm | A | 16 | Wed | |||||||
| 17 | Sat | PHIL | 7:05 pm | A | RSN | 17 | Thur | ||||||
| 18 | Sun | PHIL | 1:35 pm | A | RSN | 18 | Fri | ||||||
| 19 | Mon | 19 | Sat | ||||||||||
| 20 | Tues | LAA | 7:07 pm | H | 20 | Sun | |||||||
| 21 | Wed | LAA | 7:07 pm | H | 21 | Mon | |||||||
| 22 | Thurs | LAA | 7:07 pm | H | 22 | Tues | |||||||
| 23 | Fri | KC | 7:07 pm | H | 23 | Wed | |||||||
| 24 | Sat | KC | 1:07 pm | H | RSN | 24 | Thurs | ||||||
| 25 | Sun | KC | 1:07 pm | H | RSN | 25 | Fri | ||||||
| 26 | Mon | KC | 12:37 pm | H | 26 | Sat | |||||||
| 27 | Tues | OAK | 10:05 pm | A | RSN | 27 | Sun | ||||||
| 28 | Wed | OAK | 10:05 PM | A | RSN | 28 | Mon | ||||||
| 29 | Thurs | OAK | 3:35 pm | A | 29 | Tues | |||||||
| 30 | Fri | LAA | 10:05 pm | A | RSN | 30 | Wed | ||||||
| 31 | Sat | LAA | 9:05 pm | A | RSN | 31 | Thurs | ||||||
| TSN (0-0) | CBC (0-0) | RSN |
(0-0) |
June (0-0) | RONT (0-0) | ||||||||
| 5 | 8 | 11 | |||||||||||
| Day | Opp | Time | H\A | TV | Score | W\L | Record | WP (Record) | LP (Record) | Save | Day | ||
| 1 | Sun | LAA | 3:35 pm | A | RSN | 1 | Sun | ||||||
| 2 | Mon | 2 | Mon | ||||||||||
| 3 | Tues | NYY | 7:05 pm | A | RSN | 3 | Tues | ||||||
| 4 | Wed | NYY | 7:05 pm | A | TSN | 4 | Wed | ||||||
| 5 | Thur | NYY | 1:05 pm | A | RSN | 5 | Thur | ||||||
| 6 | Fri | BALT | 7:07 pm | H | TSN | 6 | Fri | ||||||
| 7 | Sat | BALT | 1:07 pm | H | CBC |